In this randomized controlled trial of IV alteplase for ischemic stroke, researchers evaluated CT or brain MRI scans before treatment and 24 to 48 hours after treatment for acute lesion visibility, extent, and swelling.

Researchers sought to determine whether noninvasive vagus nerve stimulation significantly reduces the amount of pain or even takes pain away entirely in patients with episodic migraine.

The concomitant use of cholinesterase inhibitors or memantine was associated with an increased rate of cognitive decline in clinical trials of patients with Alzheimer disease.

Bafiertam is a new fumarate bioequialent alternative to its prodrug, Tecfidera (dimethyl fumarate; Biogen).

Investigators reviewed patient-reported outcomes to assess treatment satisfaction with teriflunomide and also looked at feedback from physicians regarding the effectiveness of teriflunomide when used in routine clinical practice.

Investigators analyzed racial differences in the clinical features of neuromyelitis optica spectrum disorder.

Investigators examined the effect of common infections such as urinary tract infections, sepsis, and pneumonia on >300,000 patients with ischemic stroke.

Investigators sought to determine whether absence of lesions in 2 specific brain regions can distinguish Fabry disease from multiple sclerosis.

Investigators examined whether very early mobilization, started ?48 hours after onset of stroke symptoms, improves recovery and survival after stroke compared with more delayed mobilization.

Migraine with aura increased the risk for diffuse carotid thickening and migraine without aura was associated with a low risk for carotid plaques and arterial stiffening in middle-aged women.

Researchers evaluated clinical and magnetic resonance imaging data from patients with relapsing-remitting multiple sclerosis treated with alemtuzumab.

Investigators examined whether a bracelet capable of measuring heart rate and movement would be beneficial for detecting nocturnal seizures in patients with epilepsy.

Investigators sought to predict the incidence of SUDEP in people with intellectual disabilities in residential care settings and to determine its relationship with nocturnal seizures and nocturnal supervision.

The use of somatosensory temporal discrimination testing did not incite any changes in the mean velocity of index finger movements in either patients with dystonia or healthy controls.

Investigators retrospectively reviewed data to compare pregnancy prevalence and complications in women with and without multiple sclerosis.

Investigators analyzed medial temporal lobe structure, white matter lesion load, and ?-amyloid deposition in women who underwent bilateral salpingo-oophorectomy prior to reaching natural menopause.

Future research is needed to determine whether cervical musculoskeletal dysfunction causes migraine or tension-type headache-related neck pain.

Systematic review and meta-analysis provides evidence that white matter hyperintensities, brain infarcts, and cerebral microbleeds indicate a significant increased risk for stroke, dementia, and death in community-dwelling older adults.

Clinicians have a responsibility to engage in initiatives that improve the quality of health information available online.

Researchers performed contrast analysis on different imaging modalities and cross-validated results using a “unique approach integrating two meta-analytical algorithms.”